Heterogeneous malignant non Hodgkin's lymphomas as a causative disorder in lethal midline granuloma

The present report describes the results of a combined morphological, enzyme- and immunohistochemical analysis of nine cases of malignant non Hodgkin's lymphomas (NHL) clinically presenting as lethal midline granuloma. In a previous report written before antibodies directed against B and T lymp...

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1989, Vol.415 (3), p.265-273
Main Authors: LAENG, R. H, GERBER, H. A, SCHAFFNER, T, BURKI, K. H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
alpha 1-Antichymotrypsin - metabolism
alpha 1-Antitrypsin - metabolism
Antigens, Differentiation - metabolism
B-Lymphocytes - immunology
Biological and medical sciences
Female
Granuloma, Lethal Midline - etiology
Granuloma, Lethal Midline - metabolism
Granuloma, Lethal Midline - pathology
Hematologic and hematopoietic diseases
Histocompatibility Antigens - metabolism
Humans
Immunohistochemistry
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocyte Common Antigens
Lymphoma, Non-Hodgkin - complications
Lymphoma, Non-Hodgkin - metabolism
Lymphoma, Non-Hodgkin - pathology
Macrophages - immunology
Male
Medical sciences
Middle Aged
S100 Proteins - metabolism
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Summary:The present report describes the results of a combined morphological, enzyme- and immunohistochemical analysis of nine cases of malignant non Hodgkin's lymphomas (NHL) clinically presenting as lethal midline granuloma. In a previous report written before antibodies directed against B and T lymphocytes were available, a histiocytic origin of such neoplasms had been suggested. A panel of antibodies reactive with most B cells (L26, MB1, KiB3) and a majority of T cells (MT1, UCHL1) was applied on paraffin sections of formalin fixed tissues as well as antibodies directed against leukocyte common antigen (LCA), myeloid/histiocyte antigen (MAC 387), lysozyme, alpha-1-antitrypsin, alpha-1-antichymotrypsin, S-100 protein, prekeratin and immunoglobulin light chains. Enzyme histochemistry included tests for non-specific acid esterase, acid phosphatase, beta-glucuronidase and chloroacetate esterase. As a result, five T, two B and two unclassified (malignant histiocytosis probable) NHL were identified, indicating distinct heterogeneity of NHL as causative disorders in lethal midline granuloma.
ISSN:0174-7398
1432-2307
DOI:10.1007/BF00724914