Morphological clues for the diagnosis of small hepatocellular carcinomas

Histological features of 44 cases of small hepatocellular carcinoma (HCC) were examined and compared with those of large regenerative nodules. The highly differentiated type of HCC most often occurred in nodules which were less than 2 cm in diameter. Noticeably, in 9 out of 15 such cases (60.0%), tu...

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1987, Vol.411 (1), p.15-21
Main Authors: KONDO, F, HIROOKA, N, WADA, K, KONDO, Y
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy
Carcinoma, Hepatocellular - pathology
Cell Nucleus - pathology
Cytoplasm - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Nuclear Envelope - pathology
Tumors
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Summary:Histological features of 44 cases of small hepatocellular carcinoma (HCC) were examined and compared with those of large regenerative nodules. The highly differentiated type of HCC most often occurred in nodules which were less than 2 cm in diameter. Noticeably, in 9 out of 15 such cases (60.0%), tumour cells were arranged in trabeculae of almost normal thickness (normotrabecular pattern). These trabeculae, however, showed variable nuclear crowding, occasional microacinar formation, and increase in cytoplasmic basophilia. It is emphasized that the presence of this triad may be a very reliable indicator for the histological identification of early HCC, especially in examining limited material such as a biopsy specimen. However, cellular and structural atypia becomes more prominent in nodules which are larger than 2 cm.
ISSN:0174-7398
1432-2307
DOI:10.1007/bf00734509