Hypothalamic polar spongioblastoma associated with the diencephalic syndrome. Ultrastructural demonstration of a neuro-endocrine organization

A tumor was resected from the third ventricle of a four years and eleven month old girl with the diencephalic syndrome. By light microscopy, it was diagnosed as a polar spongioblastoma . Its ultrastructural study was undertaken and the features were found to be distinctive and previously unreported....

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1984-01, Vol.402 (4), p.465-474
Main Authors: de Chadarévian, J P, Guyda, H J, Hollenberg, R D
Format: Article
Language:English
Subjects:
Astrocytoma - complications
Astrocytoma - ultrastructure
Brain Neoplasms - complications
Brain Neoplasms - ultrastructure
Child, Preschool
Diencephalon - ultrastructure
Emaciation - etiology
Endocrine System Diseases - etiology
Failure to Thrive - etiology
Female
Humans
Hypothalamus - ultrastructure
Microscopy, Electron
Syndrome
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Summary:A tumor was resected from the third ventricle of a four years and eleven month old girl with the diencephalic syndrome. By light microscopy, it was diagnosed as a polar spongioblastoma . Its ultrastructural study was undertaken and the features were found to be distinctive and previously unreported. The organization of the neoplasm was similar to that of the hypothalamic neuro-endocrine systems: Cellular perivascular arrangement with intra-cytoplasmic microtubules and membrane bound dense-core granules.
ISSN:0174-7398
1432-2307
DOI:10.1007/BF00734643