Immunotactoid glomerulopathy with fingerprint immune deposits: a variant of lupus nephritis?

Immunotactoid glomerulopathy is a distinct clinico-pathological entity which has recently been defined. The term immunotactoid refers to highly organized immune depositions appearing as rod-like microtubular structures in ultrastructural examination. We describe a patient with mixed connective tissu...

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1989, Vol.415 (2), p.181-186
Main Authors: MAC-MOUNE LAI, F, KAR NENG LAI, LI, E. K, JAO YIU SUNG, TAM, J. S. L
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Crystallization
Female
Fluorescent Antibody Technique
Glomerulonephritis
Humans
Kidney Glomerulus - immunology
Kidney Glomerulus - ultrastructure
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - pathology
Lupus Nephritis - immunology
Lupus Nephritis - pathology
Medical sciences
Microscopy, Electron
Microscopy, Fluorescence
Microtubules - ultrastructure
Mixed Connective Tissue Disease - immunology
Mixed Connective Tissue Disease - pathology
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Nephrotic Syndrome - classification
Nephrotic Syndrome - immunology
Nephrotic Syndrome - pathology
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Summary:Immunotactoid glomerulopathy is a distinct clinico-pathological entity which has recently been defined. The term immunotactoid refers to highly organized immune depositions appearing as rod-like microtubular structures in ultrastructural examination. We describe a patient with mixed connective tissue disease who demonstrates characteristic features of immunotactoid glomerulopathy. The diagnosis was made after excluding amyloidosis, cryoglobulinaemia and lupus nephritis. In addition to immunotactoid microtubules, ultrastructural examination also demonstrated presence of fingerprint depositions which were intimately mixed with immunotactoid structures. Fingerprint deposits have been described in lupus nephritis and cryoglobulin-related nephropathy, but rarely in other glomerulonephritis. These unique findings in our patient may suggest a previously unsuspected relationship between the syndrome of immunotactoid glomerulopathy and systemic lupus erythematosus.
ISSN:0174-7398
1432-2307
DOI:10.1007/bf00784357