Early immunoscintigraphic localisation of a mediastinal tumour with indium 111-DTPA CEA-specific F(ab')2 monoclonal antibody fragments (BW 431/31) using second tracer isocontour technique

A female patient with steadily increasing carcinoembryonic antigen (CEA) serum levels of unknown origin was referred for immunoscintigraphy with indium 111-labelled CEA-specific monoclonal antibody. The procedure revealed a tumour, undetectable by conventional diagnostic methods. Anatomical landmark...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1990-01, Vol.17 (1-2), p.91-93
Main Authors: FROHN, J, BAUM, R. P, HAPP, J, FALK, S, RIEMANN, H. E, HÖR, G
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal
Biological and medical sciences
Carcinoembryonic Antigen - immunology
Carcinoma - diagnostic imaging
Female
Humans
Immunoglobulin Fab Fragments - immunology
Indium Radioisotopes
Investigative techniques, diagnostic techniques (general aspects)
Mediastinal Neoplasms - diagnostic imaging
Medical sciences
Pentetic Acid
Radionuclide investigations
Tomography, Emission-Computed, Single-Photon
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Summary:A female patient with steadily increasing carcinoembryonic antigen (CEA) serum levels of unknown origin was referred for immunoscintigraphy with indium 111-labelled CEA-specific monoclonal antibody. The procedure revealed a tumour, undetectable by conventional diagnostic methods. Anatomical landmarking using the second tracer isocontour technique allowed the distinction between an intra- or extrapulmonary lesion. Two months later, tumour infiltration along the aortic arch was confirmed by a targeted angio-CT scan. Upon surgery, the diagnosis was definitely established histologically (undifferentiated, solid large cell carcinoma, most probably arising from the bronchus), and staining by CEA-specific immunohistochemistry confirmed the presence of the CEA antigen.
ISSN:0340-6997
1619-7089
DOI:10.1007/BF00819410