Cyclosporine-induced transient renal hypoperfusion in adolescent transplant recipients

We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amin...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1996-02, Vol.10 (1), p.81-83
Main Authors: DELLO STROLOGO, L, MASSELLA, L, RIZZONI, G
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Child
Cyclosporine - adverse effects
Cyclosporine - pharmacokinetics
Cyclosporine - therapeutic use
Female
Glomerular Filtration Rate - drug effects
Humans
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - pharmacokinetics
Immunosuppressive Agents - therapeutic use
Kidney Transplantation - physiology
Male
Medical sciences
Renal Circulation - drug effects
Renal Plasma Flow - drug effects
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
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Summary:We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity.
ISSN:0931-041X
1432-198X
DOI:10.1007/BF00863455