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Cyclosporine-induced transient renal hypoperfusion in adolescent transplant recipients
We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amin...
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| Published in: | Pediatric nephrology (Berlin, West) West), 1996-02, Vol.10 (1), p.81-83 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c243t-1bda2a646cf16139823655cf5f2bec5f0a09b1708f628991f0048e29bdff4a6b3 |
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| cites | cdi_FETCH-LOGICAL-c243t-1bda2a646cf16139823655cf5f2bec5f0a09b1708f628991f0048e29bdff4a6b3 |
| container_end_page | 83 |
| container_issue | 1 |
| container_start_page | 81 |
| container_title | Pediatric nephrology (Berlin, West) |
| container_volume | 10 |
| creator | DELLO STROLOGO, L MASSELLA, L RIZZONI, G |
| description | We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity. |
| doi_str_mv | 10.1007/BF00863455 |
| format | article |
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Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/BF00863455</identifier><identifier>PMID: 8611366</identifier><identifier>CODEN: PENED3</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Cyclosporine - adverse effects ; Cyclosporine - pharmacokinetics ; Cyclosporine - therapeutic use ; Female ; Glomerular Filtration Rate - drug effects ; Humans ; Immunosuppressive Agents - adverse effects ; Immunosuppressive Agents - pharmacokinetics ; Immunosuppressive Agents - therapeutic use ; Kidney Transplantation - physiology ; Male ; Medical sciences ; Renal Circulation - drug effects ; Renal Plasma Flow - drug effects ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cyclosporine - adverse effects</subject><subject>Cyclosporine - pharmacokinetics</subject><subject>Cyclosporine - therapeutic use</subject><subject>Female</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Immunosuppressive Agents - pharmacokinetics</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Kidney Transplantation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Renal Circulation - drug effects</subject><subject>Renal Plasma Flow - drug effects</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNpF0E1LAzEQBuAgSq3Vi3dhD56E1Zl8NTlqsSoUvKj0tmSzCUa22SVpD_33bmuppzm8zwzMS8g1wj0CTB-e5gBKMi7ECRkjZ7RErZanZAyaYQkcl-fkIucfGJhQckRGSiIyKcfka7a1bZf7LoXoyhCbjXVNsU4m5uDiukgumrb43vZd75Lf5NDFIsTCNF3rst2Jve1bs8c29Lu1fEnOvGmzuzrMCfmcP3_MXsvF-8vb7HFRWsrZusS6MdRILq1HiUwryqQQ1gtPa2eFBwO6xikoL6nSGj0AV47quvGeG1mzCbn7u2tTl3NyvupTWJm0rRCqXTfVfzcDvvnD_aZeueZID2UM-e0hN9ma1g-P2ZCPjOopZYDsF1UHbTg</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>DELLO STROLOGO, L</creator><creator>MASSELLA, L</creator><creator>RIZZONI, G</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19960201</creationdate><title>Cyclosporine-induced transient renal hypoperfusion in adolescent transplant recipients</title><author>DELLO STROLOGO, L ; MASSELLA, L ; RIZZONI, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c243t-1bda2a646cf16139823655cf5f2bec5f0a09b1708f628991f0048e29bdff4a6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cyclosporine - adverse effects</topic><topic>Cyclosporine - pharmacokinetics</topic><topic>Cyclosporine - therapeutic use</topic><topic>Female</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Immunosuppressive Agents - pharmacokinetics</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Kidney Transplantation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Renal Circulation - drug effects</topic><topic>Renal Plasma Flow - drug effects</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DELLO STROLOGO, L</creatorcontrib><creatorcontrib>MASSELLA, L</creatorcontrib><creatorcontrib>RIZZONI, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DELLO STROLOGO, L</au><au>MASSELLA, L</au><au>RIZZONI, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclosporine-induced transient renal hypoperfusion in adolescent transplant recipients</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><addtitle>Pediatr Nephrol</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>10</volume><issue>1</issue><spage>81</spage><epage>83</epage><pages>81-83</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><coden>PENED3</coden><abstract>We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule in six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusion of inulin and amino-hippuric acid for 12 h. A fall in both GFR and RPF was observed 4-6 h after peak plasma CsA levels. No significant correlation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrotoxicity.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>8611366</pmid><doi>10.1007/BF00863455</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 1996-02, Vol.10 (1), p.81-83 |
| issn | 0931-041X 1432-198X |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF00863455 |
| source | Springer LINK Archives |
| subjects | Adolescent Biological and medical sciences Child Cyclosporine - adverse effects Cyclosporine - pharmacokinetics Cyclosporine - therapeutic use Female Glomerular Filtration Rate - drug effects Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Kidney Transplantation - physiology Male Medical sciences Renal Circulation - drug effects Renal Plasma Flow - drug effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system |
| title | Cyclosporine-induced transient renal hypoperfusion in adolescent transplant recipients |
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