Atrial fibrillation following methylprednisolone pulse therapy

Two children, one with renal manifestations of systemic lupus erythematosus and the other with idiopathic nephrotic syndrome, were treated with methylprednisolone pulses. Neither had previous evidence of underlying cardiac disease. Within 24 h of pulse therapy, they complained of palpitations and de...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1988-01, Vol.2 (1), p.29-31
Main Authors: UEDA, N, YOSHIKAWA, T, CHIHARA, M, KAWAGUCHI, S, NIINOMI, Y, YASAKI, T
Format: Article
Language:English
Subjects:
Adolescent
Atrial Fibrillation - chemically induced
Biological and medical sciences
Child
Drug toxicity and drugs side effects treatment
Female
Humans
Lupus Nephritis - drug therapy
Male
Medical sciences
Methylprednisolone - administration & dosage
Methylprednisolone - adverse effects
Nephrotic Syndrome - drug therapy
Pharmacology. Drug treatments
Toxicity: cardiovascular system
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Summary:Two children, one with renal manifestations of systemic lupus erythematosus and the other with idiopathic nephrotic syndrome, were treated with methylprednisolone pulses. Neither had previous evidence of underlying cardiac disease. Within 24 h of pulse therapy, they complained of palpitations and developed atrial fibrillation which reversed spontaneously or after anti-arrhythmic therapy. Subsequent serial electro- and echocardiograms were normal. We propose that the arrhythmias were a complication of steroid pulse therapy.
ISSN:0931-041X
1432-198X
DOI:10.1007/bf00870376