novel plant membrane proteoglycan which causes anorexia in animals

Hunger and satiety are complex interplay of several factors in human and animal species. Reduced food intake has also been observed under various pathological conditions. Earlier, we have been able to isolate an endogenous glycoprotein from erythrocyte membranes, which causes anorexia in rats. In th...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1993-03, Vol.120 (2), p.111-117
Main Authors: Kidwai, A.M, Upreti, R.K
Format: Article
Language:English
Subjects:
Amino Acids - analysis
Animals
Anorexia - chemically induced
appetite
Biological and medical sciences
Carbohydrates - analysis
cell membranes
chemical constituents of plants
Cicer arietinum
Fabaceae - chemistry
food intake
General pharmacology
hunger
Male
Medical sciences
Membrane Proteins - chemistry
Membrane Proteins - isolation & purification
Membrane Proteins - toxicity
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Proteins - chemistry
Plant Proteins - isolation & purification
Plant Proteins - toxicity
Plants, Medicinal
proteoglycans
Proteoglycans - chemistry
Proteoglycans - isolation & purification
Proteoglycans - toxicity
Rabbits
Rats
Rats, Wistar
satiety
Seeds - chemistry
Triticum - chemistry
Triticum aestivum
Vigna radiata
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Summary:Hunger and satiety are complex interplay of several factors in human and animal species. Reduced food intake has also been observed under various pathological conditions. Earlier, we have been able to isolate an endogenous glycoprotein from erythrocyte membranes, which causes anorexia in rats. In the present study, a similar anorexigenic proteoglycan from Mung bean sprout membranes has been isolated and purified. The proteoglycan (50 kDa) consisted of 70-85% carbohydrate with galactose, glucose galactosamine and mannose as the main sugars. Protein part on analysis showed higher glutamic acid and serine content. This proteoglycan reduces food intake when injected in rats deprived of food for 96 hr as well as normally fed rats, mice and rabbits without any rebound. The TCA-soluble proteoglycan from different plant sources have also been compared for their anorexigenic activity. The similarities observed among plant and animal cell membrane proteoglycans with satietins isolated from human blood plasma could be due to membrane origin of satietins.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00926083