Cisplatin induced nephrotoxicity and the modulating effect of glutathione ester

The objective of this study was to assess the therapeutic advantage of glutathione ester along with cisplatin. Comparisons were made with renal reduced glutathione, enzymatic antioxidants, and lipid peroxidation levels. Cisplatin caused differential toxic effects on renal antioxidants and lipid pero...

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Published in:Molecular and cellular biochemistry 1995-03, Vol.144 (1), p.7-11
Main Authors: Babu, E, Gopalakrishnan, V K, Sriganth, I N, Gopalakrishnan, R, Sakthisekaran, D
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Ascorbic Acid - pharmacology
Cisplatin - administration & dosage
Cisplatin - toxicity
Ferrous Compounds - pharmacology
Free Radical Scavengers - pharmacology
Free Radicals
Glutathione - analogs & derivatives
Glutathione - metabolism
Glutathione - pharmacology
Glutathione Peroxidase - analysis
Glutathione Peroxidase - antagonists & inhibitors
Kidney - drug effects
Kidney - enzymology
Kidney - pathology
Lipid Peroxidation - drug effects
Rats
Rats, Wistar
Reactive Oxygen Species - metabolism
Superoxide Dismutase - analysis
Superoxide Dismutase - antagonists & inhibitors
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Summary:The objective of this study was to assess the therapeutic advantage of glutathione ester along with cisplatin. Comparisons were made with renal reduced glutathione, enzymatic antioxidants, and lipid peroxidation levels. Cisplatin caused differential toxic effects on renal antioxidants and lipid peroxidation. However administration of glutathione ester modulates the toxic effects of cisplatin observed in renal antioxidants and lipid peroxidation. The finding that glutathione ester co-administration along with cisplatin is more effective and advantageous in protecting against the nephrotoxicity of cisplatin when it was given alone.
ISSN:0300-8177
1573-4919
DOI:10.1007/bf00926734