A spirohydantoin derivative of dimethoxytetrahydronaphthalene: an experimental anticonvulsant

A 2-spirohydantoin of 6,7-dimethoxytetrahydronaphthalene was synthesized and purified. The compound, showing structural similarities to both phenytoin and dopamine, was found to decrease spontaneous motor activity of mice and to exert a pronounced protective effect against convulsive seizures induce...

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Bibliographic Details
Published in:Neurochemical research 1984-04, Vol.9 (4), p.529-533
Main Authors: ALEXANDER, G. J, BISWAJIT SINHA, CHATTERJIE, N
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Electroshock
Exploratory Behavior - drug effects
Hydantoins - chemical synthesis
Hydantoins - pharmacology
Male
Medical sciences
Mice
Motor Activity - drug effects
Neuropharmacology
Pentylenetetrazole - toxicity
Pharmacology. Drug treatments
Seizures - physiopathology
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Summary:A 2-spirohydantoin of 6,7-dimethoxytetrahydronaphthalene was synthesized and purified. The compound, showing structural similarities to both phenytoin and dopamine, was found to decrease spontaneous motor activity of mice and to exert a pronounced protective effect against convulsive seizures induced by pentylenetetrazol (Metrazol).
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00964379