Immunochemical and ultrastructural investigations in a patient with cold-agglutinine-active monoclonal IgMK-gammopathy

A patient with "chronic cold-agglutinin disease" is described. Initially, the process was a benign monoclonal gammopathy. After an intervall of 6 years clinical, cytomorphological and immunochemical studies showed progress towards malignancy. In the bone marrow intranuclear lipid-like incl...

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Bibliographic Details
Published in:Blut 1977-04, Vol.34 (4), p.299-304
Main Authors: Ottó, S, Börzonyi, M, Eckhardt, S, Mohay, A, Gergely, J, Kellner, R
Format: Article
Language:English
Subjects:
Agglutinins
Autoantibodies
Bone Marrow - ultrastructure
Cold Temperature
Humans
Hypergammaglobulinemia - pathology
Immunoglobulin kappa-Chains
Immunoglobulin M
Male
Microscopy, Electron
Paraproteinemias - pathology
Plasma Cells
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Summary:A patient with "chronic cold-agglutinin disease" is described. Initially, the process was a benign monoclonal gammopathy. After an intervall of 6 years clinical, cytomorphological and immunochemical studies showed progress towards malignancy. In the bone marrow intranuclear lipid-like inclusions appeared in the plasma cells.
ISSN:0006-5242
1432-0584
DOI:10.1007/BF00996206