Decrease of normotest/thrombotest discrepancy in non-contacted coumarin plasma after glass or ellagic acid activation

Activation of coumarin plasmas in glass tubes for 60 min resulted in a clear shortening of Thrombotest clotting times. Normotest clotting times were shortened too but to a much lesser extent. As a consequence the Normotest (NT)/Thrombotest (TT) discrepancy which was quite large at 0 time, became pro...

Full description

Saved in:
Bibliographic Details
Published in:Blut 1976-07, Vol.33 (1), p.41-48
Main Authors: Girolami, A, Patrassi, G, Burul, A
Format: Article
Language:English
Subjects:
Blood Coagulation Tests
Coumarins
Ellagic Acid - pharmacology
Factor VII
Glass
Humans
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Activation of coumarin plasmas in glass tubes for 60 min resulted in a clear shortening of Thrombotest clotting times. Normotest clotting times were shortened too but to a much lesser extent. As a consequence the Normotest (NT)/Thrombotest (TT) discrepancy which was quite large at 0 time, became progressively smaller. This phenomenon was observed both in undiluted and 6:10 diluted plasma. After ellagic acid activation a similar phenomenon was noted even though a less pronounced shortening of Thrombotest was noted. These data suggest that Thrombotest is very sensitive to contact phase and to factor VII activation and not to any coumarin-induced inhibitors.
ISSN:0006-5242
1432-0584
DOI:10.1007/BF01005211