Bioavailability of metoprolol in young adults and the elderly, with additional studies on the effects of metoclopramide and probanthine

The bioavailability of metoprolol was studied in eight healthy young and seven healthy elderly volunteers. Large interindividual differences in the bioavailability of metoprolol were observed in both groups. However, there was no significant difference in AUC, peak plasma concentration or eliminatio...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 1983-01, Vol.25 (3), p.353-356
Main Authors: BRIANT, R. H, DORRINGTON, R. E, FERRY, D. G, PAXTON, J. W
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Biological and medical sciences
Biological Availability
Drug Interactions
Female
General pharmacology
Humans
Male
Medical sciences
Metoclopramide - pharmacology
Metoprolol - metabolism
Middle Aged
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Propantheline - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The bioavailability of metoprolol was studied in eight healthy young and seven healthy elderly volunteers. Large interindividual differences in the bioavailability of metoprolol were observed in both groups. However, there was no significant difference in AUC, peak plasma concentration or elimination half-life between young and elderly, but time to peak concentration was significantly longer in the elderly. Pretreatment with metoclopramide had no effect on AUC but caused significant increases in peak concentration and decreases in time to peak concentration in both groups. Probanthine pretreatment (only to the young) resulted in a significant decrease in peak concentration of metoprolol and a significant increase in time to peak concentration but had no effect on the AUC. These results suggest that alterations in gastric emptying and gut motility due to ageing or other drugs have no effect on the overall availability of metoprolol to the systemic circulation but may have significant effects on the time to peak plasma concentration and peak concentration achieved after a single oral dose.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF01037947