Experience with synthetic secretin in the treatment of duodenal ulcer

Hospitalized male patients with endoscopically verified duodenal ulcer were studied to determine the effect of secretin on the clinical course of their disease. Seven patients received synthetic porcine secretin, 333 mug subcutaneously every 4 hr for 10 days, and 6 patients received placebo injectio...

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Bibliographic Details
Published in:American journal of digestive diseases 1976-11, Vol.21 (11), p.921-925
Main Authors: Henn, R M, Selcon, S, Sturdevant, R A, Isenberg, J I, Grossman, M I
Format: Article
Language:English
Subjects:
Adult
Amylases - urine
Antacids - administration & dosage
Clinical Trials as Topic
Drug Evaluation
Duodenal Ulcer - drug therapy
Gastric Acidity Determination
Humans
Isoamylase - blood
Male
Middle Aged
Secretin - adverse effects
Secretin - therapeutic use
Wound Healing - drug effects
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Summary:Hospitalized male patients with endoscopically verified duodenal ulcer were studied to determine the effect of secretin on the clinical course of their disease. Seven patients received synthetic porcine secretin, 333 mug subcutaneously every 4 hr for 10 days, and 6 patients received placebo injections on the same schedule. Repeat endoscopy was performed within 48 hr of completing the 10-day treatment period. The trial was discontinued because of transient, asymptomatic, hyperamylasemia in secretin-treated patients. Although significant gastric alkalinization could be reproducibly demonstrated in secretin-treated patients, secretin was not more effective than placebo in relieving pain or healing duodenal ulcer. However, because the number of patients was small, definitive conclusions regarding efficacy of secretin in ulcer treatment could not be drawn.
ISSN:0002-9211
1573-2568
DOI:10.1007/BF01071902