A bioptic study of gastrointestinal mucosa in cholera patients during an epidemic in southern Italy

A histological biopsy study of gastric and jejunal mucosa of eight acute cholera patients during an epidemic in Southern Italy was carried out. The study demonstrated in all patients an intact epithelial lining of gastric and jejunal mucosa, a moderate degenerative process of enterocytes, presence o...

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Bibliographic Details
Published in:American journal of digestive diseases 1976-08, Vol.21 (8), p.613-617
Main Authors: Pastore, G, Schiraldi, G, Fera, G, Sforza, E, Schiraldi, O
Format: Article
Language:English
Subjects:
Biopsy
Cholera - pathology
Disease Outbreaks
Epithelial Cells
Epithelium - pathology
Gastric Mucosa - pathology
Humans
Intestinal Mucosa - pathology
Italy
Jejunum - pathology
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Summary:A histological biopsy study of gastric and jejunal mucosa of eight acute cholera patients during an epidemic in Southern Italy was carried out. The study demonstrated in all patients an intact epithelial lining of gastric and jejunal mucosa, a moderate degenerative process of enterocytes, presence of inflammatory lesions manifested by edema, vascular congestion, mononuclear cell infiltrate of lamina propria, and discharge of goblet-cells mucus. These changes reverted to normal in a few days. The authors emphasize that, contrary to cholera patients of Asiatic areas in whom an underlying chronic spruelike enteropathy is very common, the histological picture observed in Western patients may be considered more specific since Vibrio cholerae acts upon a normal intestinal mucosa.
ISSN:0002-9211
1573-2568
DOI:10.1007/BF01071953