Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs

Simultaneous measurement of plasma motilin concentration and gastrointestinal contractile activity was make in 12 healthy dogs. Plasma motilin concentration was measured by radioimmunoassay and gastrointestinal contractile activity was monitored by means of chronically implanted force transducers. D...

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Bibliographic Details
Published in:American journal of digestive diseases 1978-10, Vol.23 (10), p.929-935
Main Authors: Itoh, Z, Takeuchi, S, Aizawa, I, Mori, K, Taminato, T, Seino, Y, Imura, H, Yanaihara, N
Format: Article
Language:English
Subjects:
Animals
Digestion
Digestive System Physiological Phenomena
Dogs
Eating
Female
Gastrins - blood
Gastrointestinal Hormones - blood
Gastrointestinal Motility
Jejunum
Male
Motilin - blood
Peristalsis
Pyloric Antrum
Time Factors
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Summary:Simultaneous measurement of plasma motilin concentration and gastrointestinal contractile activity was make in 12 healthy dogs. Plasma motilin concentration was measured by radioimmunoassay and gastrointestinal contractile activity was monitored by means of chronically implanted force transducers. During the interdigestive state, it was found that the plasma motilin concentration increased in complete accordance with the cyclical interdigestive contractions of the stomach. Furthermore, plasma motilin concentration was lowered by the ingestion of food, and it reamined low as long as the gastric motor activity was in the digestive pattern. Since, as reported previously the interdigestive contractions can be induced by tthe exogenous administration of motilin, we concluded that (1) motilin is released at constant intervals during the interdigestive state, and this release is suppressed by the ingestion of food; (2) motilin induces the interdigestive contractions of the stomach and duodenum; and (3) motilin is an interdigestive hormone and is the only known polypeptide hormone of the gut whose release is not induced by a meal.
ISSN:0002-9211
1573-2568
DOI:10.1007/bf01072469