Therapy with gastrin antibody in the Zollinger-Ellison syndrome

The therapeutic effectiveness of parenterally administered rabbit antigastrin antibody was evaluated in a patient with the Zollinger-Ellison syndrome who had a fasting serum gastrin level of 3020 pg/ml and a basal gastric acid secretion of 48.9 mEq/hr. Control globulin reduced gastric secretion to 3...

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Bibliographic Details
Published in:American journal of digestive diseases 1976-03, Vol.21 (3), p.201-204
Main Authors: Hughes, W S, Hughes, J B, Ritzmann, S E
Format: Article
Language:English
Subjects:
Adult
Animals
Antibodies - administration & dosage
Antibody Specificity
Binding, Competitive
Dogs
Female
Gastrins - antagonists & inhibitors
Gastrins - blood
Gastrins - immunology
Humans
Immunity, Maternally-Acquired
Injections, Intravenous
Rabbits
Zollinger-Ellison Syndrome - blood
Zollinger-Ellison Syndrome - drug therapy
Zollinger-Ellison Syndrome - immunology
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Summary:The therapeutic effectiveness of parenterally administered rabbit antigastrin antibody was evaluated in a patient with the Zollinger-Ellison syndrome who had a fasting serum gastrin level of 3020 pg/ml and a basal gastric acid secretion of 48.9 mEq/hr. Control globulin reduced gastric secretion to 32 mEq/hr. Gastrin antibody reduced it futher to 8.7 mEq/hr. Betazole hydrochloride which was given 75 min after administration of gastrin antibody stimulated acid secretion to 57.2 mEq/hr. One day later basal acid secretion was uninhibited although some antibody activity was present in the patient's serum. The results suggested that gastrin antibody acutely inhibited basal but not betazole-stimulated secretion.
ISSN:0002-9211
1573-2568
DOI:10.1007/BF01095891