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Therapy with gastrin antibody in the Zollinger-Ellison syndrome
The therapeutic effectiveness of parenterally administered rabbit antigastrin antibody was evaluated in a patient with the Zollinger-Ellison syndrome who had a fasting serum gastrin level of 3020 pg/ml and a basal gastric acid secretion of 48.9 mEq/hr. Control globulin reduced gastric secretion to 3...
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| Published in: | American journal of digestive diseases 1976-03, Vol.21 (3), p.201-204 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c282t-15fe3fe0df616b75e396126c2ac43531afd0820dd02149a9de101e594be624023 |
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| cites | cdi_FETCH-LOGICAL-c282t-15fe3fe0df616b75e396126c2ac43531afd0820dd02149a9de101e594be624023 |
| container_end_page | 204 |
| container_issue | 3 |
| container_start_page | 201 |
| container_title | American journal of digestive diseases |
| container_volume | 21 |
| creator | Hughes, W S Hughes, J B Ritzmann, S E |
| description | The therapeutic effectiveness of parenterally administered rabbit antigastrin antibody was evaluated in a patient with the Zollinger-Ellison syndrome who had a fasting serum gastrin level of 3020 pg/ml and a basal gastric acid secretion of 48.9 mEq/hr. Control globulin reduced gastric secretion to 32 mEq/hr. Gastrin antibody reduced it futher to 8.7 mEq/hr. Betazole hydrochloride which was given 75 min after administration of gastrin antibody stimulated acid secretion to 57.2 mEq/hr. One day later basal acid secretion was uninhibited although some antibody activity was present in the patient's serum. The results suggested that gastrin antibody acutely inhibited basal but not betazole-stimulated secretion. |
| doi_str_mv | 10.1007/BF01095891 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0002-9211 |
| ispartof | American journal of digestive diseases, 1976-03, Vol.21 (3), p.201-204 |
| issn | 0002-9211 1573-2568 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_BF01095891 |
| source | Springer LINK Archives |
| subjects | Adult Animals Antibodies - administration & dosage Antibody Specificity Binding, Competitive Dogs Female Gastrins - antagonists & inhibitors Gastrins - blood Gastrins - immunology Humans Immunity, Maternally-Acquired Injections, Intravenous Rabbits Zollinger-Ellison Syndrome - blood Zollinger-Ellison Syndrome - drug therapy Zollinger-Ellison Syndrome - immunology |
| title | Therapy with gastrin antibody in the Zollinger-Ellison syndrome |
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