The fertilization of human oocytes by spermatozoa from men with antispermatozoal antibodies in semen

Seventy-two couples, including 15 with antispermatozoal antibodies in the male partner's semen, were studied in a program of in vitro fertilization and embryo transfer. Cases were further subclassified as normospermic or oligospermic and antispermatozoal antibodies were assessed with categoriza...

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Bibliographic Details
Published in:Journal of In Vitro Fertilization and Embryo Transfer 1986-12, Vol.3 (6), p.350-352
Main Authors: JUNK, S. M, MATSON, P. L, YOVICH, J. M, BOOTSMA, B, YOVICH, J. L
Format: Article
Language:English
Subjects:
Autoantibodies - immunology
Biological and medical sciences
Birth control
Female
Fertilization in Vitro
Gynecology. Andrology. Obstetrics
Humans
Immunoglobulin A - immunology
Immunoglobulin G - immunology
Infertility, Male - immunology
Male
Medical sciences
Oligospermia - physiopathology
Semen - immunology
Spermatozoa - immunology
Sterility. Assisted procreation
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Summary:Seventy-two couples, including 15 with antispermatozoal antibodies in the male partner's semen, were studied in a program of in vitro fertilization and embryo transfer. Cases were further subclassified as normospermic or oligospermic and antispermatozoal antibodies were assessed with categorization into the respective human immunoglobulin classes as determined using the indirect immunobead test. The study reveals that fertilization is significantly reduced (P less than 0.001) only if both IgA and IgG antibodies are present in semen but there is no reduction if either class is present alone. The fertilization rate of oocytes is significantly reduced (P less than 0.001) by sperm from oligospermic samples, and there is a further reduction in those cases with combined IgA/IgG antispermatozoal antibodies.
ISSN:0740-7769
2331-3315
1573-7330
DOI:10.1007/BF01133246