The sequential use of a luteinizing hormone-releasing hormone (LH-RH) agonist and human menopausal gonadotropins to stimulate folliculogenesis in patients with resistant ovaries

The diagnostic response toward the administration of a luteinizing hormone-releasing hormone (LH-RH) analogue in the early follicular phase has been used sequentially with conventional human menopausal gonadotropin (hMG) treatment in patients who had previously failed to develop multiple follicles i...

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Bibliographic Details
Published in:Journal of In Vitro Fertilization and Embryo Transfer 1988-02, Vol.5 (1), p.38-42
Main Authors: SHARMA, V, WILLIAMS, J, COLLINS, W, RIDDLE, A, MASON, B, WHITEHEAD, M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Birth control
Buserelin - therapeutic use
Drug Combinations - pharmacology
Female
Fertilization - drug effects
Follicular Phase - drug effects
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Gonadotropin-Releasing Hormone - pharmacology
Gynecology. Andrology. Obstetrics
Humans
Infertility, Female - therapy
Male
Medical sciences
Menotropins - pharmacology
Ovary - physiopathology
Pituitary Gland - drug effects
Pregnancy
Sterility. Assisted procreation
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Summary:The diagnostic response toward the administration of a luteinizing hormone-releasing hormone (LH-RH) analogue in the early follicular phase has been used sequentially with conventional human menopausal gonadotropin (hMG) treatment in patients who had previously failed to develop multiple follicles in response to a combination of hMG and clomiphene citrate. Nine of fourteen patients (64%) showed an increase in the number of preovulatory follicles and five subjects reached oocyte recovery for the first time. Two patients (22%) became pregnant after in vitro fertilization and embryo transfer during the treatment cycle and had healthy babies. It is suggested that this treatment regimen may be advantageous in some patients with resistant ovaries.
ISSN:0740-7769
2331-3315
1573-7330
DOI:10.1007/BF01138869