The role of transferrin and citrate in cellular uptake of aluminium

The ability of human erythroleukaemia K562 cells to take up aluminium from Al-transferrin and Al-citrate has been examined. Uptake from Al-transferrin was dose-dependent over the range 68-544 ng/ml of aluminium, and increased over a 12-day period. In contrast, uptake from Al-citrate was low even at...

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Bibliographic Details
Published in:Biology of metals 1991-01, Vol.4 (3), p.173-175
Main Authors: MCGREGOR, S. J, BROCK, J. H, HALLS, D
Format: Article
Language:English
Subjects:
Aluminum - metabolism
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Cell Division
Citrates - metabolism
Citrates - physiology
Citric Acid
Fundamental and applied biological sciences. Psychology
Humans
Kinetics
Leukemia, Erythroblastic, Acute
Proteins
Reproducibility of Results
Transferrin - metabolism
Transferrin - physiology
Tumor Cells, Cultured
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Summary:The ability of human erythroleukaemia K562 cells to take up aluminium from Al-transferrin and Al-citrate has been examined. Uptake from Al-transferrin was dose-dependent over the range 68-544 ng/ml of aluminium, and increased over a 12-day period. In contrast, uptake from Al-citrate was low even at an aluminium concentration of 6800 ng/ml and did not increase over time. Neither form of aluminium greatly affected cell growth. It is concluded that Al-transferrin, rather than Al-citrate, is the physiologically relevant form of this metal with respect to cellular uptake, but that any metabolic abnormalities induced by aluminium do not affect proliferation of this cell line.
ISSN:0933-5854
1572-8773
DOI:10.1007/BF01141310