Esophageal carcinoma in house musk shrews, Suncus murinus (Insectivora), induced by N-methyl-N'-nitro-N-nitrosoguanidine

Female 6-week-old shrews were given a solution of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) at a concentration of 50 micrograms/ml or 100 micrograms/ml in the drinking water. All 11 shrews receiving 100 micrograms/ml MNNG died 8-13 days after the beginning of carcinogen administration and 6 o...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1993-12, Vol.119 (12), p.717-720
Main Authors: TSUBURA, A, SENZAKI, H, TAKAHASHI, H, OYAIZU, T, MORII, S
Format: Article
Language:English
Subjects:
Animal tumors. Experimental tumors
Animals
Biological and medical sciences
Carcinoma, Squamous Cell - chemically induced
Carcinoma, Squamous Cell - pathology
Disease Models, Animal
Esophageal Neoplasms - chemically induced
Esophageal Neoplasms - pathology
Experimental digestive system and abdominal tumors
Female
Medical sciences
Methylnitronitrosoguanidine - toxicity
Papilloma - chemically induced
Papilloma - pathology
Shrews
Tumors
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Summary:Female 6-week-old shrews were given a solution of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) at a concentration of 50 micrograms/ml or 100 micrograms/ml in the drinking water. All 11 shrews receiving 100 micrograms/ml MNNG died 8-13 days after the beginning of carcinogen administration and 6 of the 20 shrews receiving 50 micrograms/ml MNNG died after 10-54 days. When animals were between 43 and 54 weeks of age, multiple esophageal lesions were evoked in all 14 that had received 50 micrograms/ml MNNG for 30 weeks. All shrews developed a protruding, ulcerative, or superficial type of squamous-cell carcinoma of the esophagus, accompanied by papillomas. Local invasion was seen in squamous-cell carcinoma but no distant metastasis was noted. None of the 5 control shrews developed any esophageal abnormality. No gastric adenocarcinoma, intestinal sarcoma, or other tumors were induced with MNNG. It can be concluded that MNNG has a carcinogenic effect on shrew esophageal epithelium.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF01195342