Effects of low-dose human chorionic gonadotropin on corpus luteum function after embryo transfer

This paper reports the effect of low-dose human chorionic gonadotropin (hCG) on the levels of serum hCG, progesterone, and estradiol, luteal-phase length, and conception in 20 patients undergoing in vitro fertilization and embryo transfer (IVF-ET). Alternate patients in a group of 20 received 1000 I...

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Bibliographic Details
Published in:Journal of In Vitro Fertilization and Embryo Transfer 1985-12, Vol.2 (4), p.190-194
Main Authors: MAHADEVAN, M. M, LEADER, A, TAYLOR, P. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Birth control
Chorionic Gonadotropin - administration & dosage
Chorionic Gonadotropin - blood
Corpus Luteum Maintenance - drug effects
Embryo Implantation - drug effects
Embryo Transfer
Estradiol - blood
Female
Fertilization in Vitro
Gynecology. Andrology. Obstetrics
Humans
Luteal Phase - drug effects
Medical sciences
Pregnancy
Progesterone - blood
Sterility. Assisted procreation
Time Factors
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Summary:This paper reports the effect of low-dose human chorionic gonadotropin (hCG) on the levels of serum hCG, progesterone, and estradiol, luteal-phase length, and conception in 20 patients undergoing in vitro fertilization and embryo transfer (IVF-ET). Alternate patients in a group of 20 received 1000 IU hCG on the day of embryo transfer and 3 days after. Six and 9 days from embryo transfer 2000 IU hCG was given. The remaining patients served as controls. No patients in the treated group and four in the control group became pregnant. The endocrine profiles with respect to hCG, progesterone, and estradiol levels were similar in the treated patients compared with pregnant patients in the control group. Treated patients had significantly longer (18.0 +/- 1.1 days) luteal phases compared with nonpregnant patients in the control group (12.5 +/- 1.2 days), indicating that low-dose hCG prolonged the life of the corpus luteum. It was concluded that while the administration of low-dose hCG prolonged the life of the corpus luteum, it did not apparently improve the conception rate.
ISSN:0740-7769
2331-3315
1573-7330
DOI:10.1007/BF01201796