Time and dose dependency of bone-sarcomas in patients injected with radium-224

The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear-quadratic dose relation. The deduced dose dependency a...

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Bibliographic Details
Published in:Radiation and environmental biophysics 1988-01, Vol.27 (2), p.103-114
Main Authors: Chmelevsky, D, Kellerer, A M, Land, C E, Mays, C W, Spiess, H
Format: Article
Language:English
Subjects:
Adult
Dose-Response Relationship, Radiation
Female
Germany
Humans
Male
Mathematics
Neoplasms, Radiation-Induced
Osteosarcoma - epidemiology
Osteosarcoma - etiology
Radium - adverse effects
Risk Factors
Time Factors
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Summary:The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear-quadratic dose relation. The deduced dose dependency agrees well with a previous analysis in terms of a non-parametric proportional hazards model, and confirms the temporal distribution which has been used in the Radioepidemiological Tables of NIH. However, the linear-quadratic dose-response model gives a risk estimate for low doses which is somewhat less than half that obtained under the assumption of linearity.
ISSN:0301-634X
1432-2099
DOI:10.1007/BF01214600