Acetylsalicylic acid inhibition of n-butyl-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats

We examined the effect of acetylsalicylic acid (ASA) on n-butyl-(4-hydroxybutyl)nitrosamine (BHBN)-induced bladder carcinogenesis in male Wistar rats. Of 29 rats that received 0.05% BHBN in their drinking water for 9 weeks, 8 developed bladder cancer. Only 1 out of 29 rats that received 0.1% ASA in...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1993-08, Vol.119 (8), p.482-485
Main Authors: KLÄN, R, KNISPEL, H. H, MEIER, T
Format: Article
Language:English
Subjects:
Animal tumors. Experimental tumors
Animals
Anticarcinogenic Agents - pharmacology
Aspirin - pharmacology
Biological and medical sciences
Butylhydroxybutylnitrosamine
Experimental renal and urinary tract tumors
Male
Medical sciences
Rats
Rats, Wistar
Tumors
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - prevention & control
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Summary:We examined the effect of acetylsalicylic acid (ASA) on n-butyl-(4-hydroxybutyl)nitrosamine (BHBN)-induced bladder carcinogenesis in male Wistar rats. Of 29 rats that received 0.05% BHBN in their drinking water for 9 weeks, 8 developed bladder cancer. Only 1 out of 29 rats that received 0.1% ASA in their diet for 20 weeks, including the period of BHBN consumption, developed a tumor. That difference is statistically significant. Bladder weight was significantly higher in rats given BHBN than in controls and in rats given both BHBN and ASA. We conclude that ASA inhibits BHBN-induced bladder carcinogenesis.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF01215929