The glutamate antagonist riluzole suppresses intracortical facilitation

The effect of the glutamate antagonist riluzole on excitatory and inhibitory phenomena in the human motor system was studied by transcranial magnetic stimulation (TMS) and peripheral electrical nerve stimulation. The motor threshold, the intracortical inhibition and intracortical facilitation as ass...

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Bibliographic Details
Published in:Journal of Neural Transmission 1997-01, Vol.104 (11-12), p.1207-1214
Main Authors: LIEPERT, J, SCHWENKREIS, P, TEGENTHOFF, M, MALIN, J.-P
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cerebral Cortex - drug effects
Cerebral Cortex - physiology
Electromagnetic Fields
Electrophysiology
Excitatory Amino Acid Antagonists - adverse effects
Excitatory Amino Acid Antagonists - pharmacology
Fundamental and applied biological sciences. Psychology
Glutamic Acid - physiology
Humans
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Movement - drug effects
Movement - physiology
Peripheral Nervous System - drug effects
Peripheral Nervous System - physiology
Riluzole - adverse effects
Riluzole - pharmacology
Spinal Cord - drug effects
Vertebrates: nervous system and sense organs
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Summary:The effect of the glutamate antagonist riluzole on excitatory and inhibitory phenomena in the human motor system was studied by transcranial magnetic stimulation (TMS) and peripheral electrical nerve stimulation. The motor threshold, the intracortical inhibition and intracortical facilitation as assessed by paired TMS, the cortical and peripheral silent periods, F wave amplitudes and F wave latencies were measured. Riluzole suppressed the intracortical facilitation whereas other parameters remained unchanged, indicating that the neurotransmitter glutamate is mainly involved in facilitatory mechanisms in the motor system.
ISSN:0300-9564
1435-1463
DOI:10.1007/bf01294721