Cimetidine or propantheline combined with antacid therapy for short-term treatment of duodenal ulcer

Seventy-one patients with duodenal ulcer disease completed a 3- to 6-week controlled randomized trial in which cimetidine (1 g daily) was compared with an optimally effective dose of propantheline. Both groups had free access to an antacid suspension. There were no significant differences between th...

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Bibliographic Details
Published in:Digestive diseases and sciences 1982-05, Vol.27 (5), p.388-393
Main Authors: Adami, H O, Björklund, O, Enander, L K, Gustavsson, S, Lööf, L, Nordahl, A, Rosén, A
Format: Article
Language:English
Subjects:
Adult
Aged
Antacids - therapeutic use
Cimetidine - adverse effects
Cimetidine - therapeutic use
Clinical Trials as Topic
Drug Therapy, Combination
Duodenal Ulcer - drug therapy
Endoscopy
Female
Guanidines - therapeutic use
Humans
Male
Middle Aged
Pain - drug therapy
Patient Compliance
Propantheline - adverse effects
Propantheline - therapeutic use
Pylorus
Stomach Ulcer - drug therapy
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Summary:Seventy-one patients with duodenal ulcer disease completed a 3- to 6-week controlled randomized trial in which cimetidine (1 g daily) was compared with an optimally effective dose of propantheline. Both groups had free access to an antacid suspension. There were no significant differences between the groups concerning ulcer healing, relief of ulcer symptoms, antacid consumption, or patient compliance. After 3 weeks of treatment, endoscopic examination revealed complete ulcer healing in 63% of the cimetidine and 47% of the propantheline treated patients. The corresponding figures after 6 weeks were 94% and 86%, respectively. After 12 weeks, ulcer recurrence was confirmed in 26% of the cimetidine- and 23% of the propantheline-treated patients. Except for the absence of anticholinergic adverse reactions, no significant advantages could be confirmed for combined cimetidine and antacid treatment.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01295645