Changes of systemic prostacyclin and thromboxane A2 in sodium taurocholate- and cerulein-induced acute pancreatitis in rats

Systemic prostacyclin and thromboxane A2 production in rat experimental acute pancreatitis has been evaluated by measuring the urinary excretion of the 2,3-dinor 6-keto prostaglandin F1 alpha and 2,3-dinor thromboxane B2, respectively. Acute pancreatitis was induced by intraductal administration of...

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Published in:Digestive diseases and sciences 1993, Vol.38 (1), p.33-38
Main Authors: CLOSA, D, ROSELLO-CATAFAU, J, MARTRAT, A, HOTTER, G, BULBENA, O, FERNANDEZ-CRUZ, L, GELPI, E
Format: Article
Language:English
Subjects:
6-Ketoprostaglandin F1 alpha - analogs & derivatives
6-Ketoprostaglandin F1 alpha - urine
Acute Disease
Amylases - blood
Animals
Biological and medical sciences
Ceruletide
Epoprostenol - metabolism
Gabexate - pharmacology
Gastroenterology. Liver. Pancreas. Abdomen
Lipase - blood
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Other diseases. Semiology
Pancreatitis - chemically induced
Pancreatitis - metabolism
Phospholipases A - metabolism
Phospholipases A2
Rats
Rats, Sprague-Dawley
Taurocholic Acid
Thromboxane A2 - metabolism
Thromboxane B2 - analogs & derivatives
Thromboxane B2 - urine
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Summary:Systemic prostacyclin and thromboxane A2 production in rat experimental acute pancreatitis has been evaluated by measuring the urinary excretion of the 2,3-dinor 6-keto prostaglandin F1 alpha and 2,3-dinor thromboxane B2, respectively. Acute pancreatitis was induced by intraductal administration of 4.5% sodium taurocholate (0.1 ml/100 mg body weight) and intravenous cerulein perfusion (5 micrograms/kg/hr) for 6 hr, respectively. Urinary excretion of 2,3-dinor 6-keto prostaglandin F1 alpha and 2,3-dinor thromboxane B2 were much more important in sodium taurocholate- than in cerulein-induced acute pancreatitis. These data confirm an altered prostacyclin and thromboxane metabolism occurring in experimental acute pancreatitis. Phospholipase A2 activity and the effect of gabexate mesilate on the arachidonate metabolism were also evaluated.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01296770