Is there a relationship between hypoxia, contact resistance, and intercellular communication?

This investigation addresses the shape of radiation survival curves of cells cultured as multicell spheroids. It is shown that spheroids of cells capable of intercellular communication by gap-junctions display survival curves lacking a radioresistant fraction of hypoxic cells. Compared to the corres...

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Published in:Radiation and environmental biophysics 1983-01, Vol.22 (3), p.209-214
Main Authors: Dertinger, H, Guichard, M, Malaise, E P
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion
Cell Communication
Cell Survival - radiation effects
Cells, Cultured - radiation effects
Contact Inhibition
Cricetinae
Dose-Response Relationship, Radiation
Humans
Hypoxia
Mice
Rats
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container_title Radiation and environmental biophysics
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creator Dertinger, H
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Malaise, E P
description This investigation addresses the shape of radiation survival curves of cells cultured as multicell spheroids. It is shown that spheroids of cells capable of intercellular communication by gap-junctions display survival curves lacking a radioresistant fraction of hypoxic cells. Compared to the corresponding monolayers, these spheroid survival curves exhibit a uniform increase in radioresistance due to the "contact effect". In contrast, biphasic survival curves indicative of hypoxic cells are obtained with non-communicating spheroids, however, without indication of a contact effect. Evidence is presented that this relationship between intercellular communication, hypoxia, and contact effect may possibly also hold for survival curves of solid tumors.
doi_str_mv 10.1007/BF01323710
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ispartof Radiation and environmental biophysics, 1983-01, Vol.22 (3), p.209-214
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source Springer Online Journal Archives (Through 1996)
subjects Animals
Cell Adhesion
Cell Communication
Cell Survival - radiation effects
Cells, Cultured - radiation effects
Contact Inhibition
Cricetinae
Dose-Response Relationship, Radiation
Humans
Hypoxia
Mice
Rats
title Is there a relationship between hypoxia, contact resistance, and intercellular communication?
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