Lymphatic role in the pathogenesis of fat malabsorption in liver cirrhosis in rats

Intestinal fat absorption was examined in rats with CCl4-induced liver cirrhosis. Marked lymphangiectasia of the small intestine was observed in rats after CCl4 was given subcutaneously biweekly for 10--12 weeks. Intestinal epithelial uptake of linoleic acid administered in the loop was not impaired...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 1982-11, Vol.27 (11), p.1030-1036
Main Authors: Miura, S, Asakura, H, Munakata, Y, Kobayashi, K, Yoshioka, M, Morishita, T, Tsuchiya, M
Format: Article
Language:English
Subjects:
Animals
Carbon Tetrachloride
Intestine, Small - ultrastructure
Linoleic Acid
Linoleic Acids - physiology
Lipids - physiology
Liver Cirrhosis - chemically induced
Liver Cirrhosis - metabolism
Liver Cirrhosis - pathology
Liver Cirrhosis - physiopathology
Lymphatic System - physiopathology
Malabsorption Syndromes - metabolism
Malabsorption Syndromes - physiopathology
Male
Rats
Rats, Inbred Strains
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intestinal fat absorption was examined in rats with CCl4-induced liver cirrhosis. Marked lymphangiectasia of the small intestine was observed in rats after CCl4 was given subcutaneously biweekly for 10--12 weeks. Intestinal epithelial uptake of linoleic acid administered in the loop was not impaired, but accumulation of lipid droplets in the intestinal epithelial cells and disturbed lymphatic transport of absorbed fat were observed in these rats. These data suggest that lymphostasis of the intestine may play an important role in fat malabsorption in liver cirrhosis.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01391751