Counteraction of cyanide poisoning by thiosulphate when administering sodium nitroprusside as a hypotensive treatment

A 42-year old patient received a continuous infusion of sodium nitroprusside (SNP) at a dosage rate of 600 microgram/min for approximately four days. On the third day of treatment a dangerous high level of cyanide was measured in the blood. When an additional continuous infusion of sodium thiosulpha...

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Bibliographic Details
Published in:Klinische Wochenschrift 1979-09, Vol.57 (17), p.905-907
Main Authors: Schulz, V, Bonn, R, Kämmerer, H, Kriegel, R, Ecker, N
Format: Article
Language:English
Subjects:
Adult
Antidotes
Antihypertensive Agents - therapeutic use
Cyanides - blood
Ferricyanides - therapeutic use
Humans
Male
Nitroprusside - poisoning
Nitroprusside - therapeutic use
Thiosulfates - therapeutic use
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Summary:A 42-year old patient received a continuous infusion of sodium nitroprusside (SNP) at a dosage rate of 600 microgram/min for approximately four days. On the third day of treatment a dangerous high level of cyanide was measured in the blood. When an additional continuous infusion of sodium thiosulphate at five times the molar concentration of the SNP was given, this cyanide level dropped over a period of 7h to one-seventh of its initial value. The thiosulphate did not reduce the effectiveness of the SNP in lowering the blood pressure.
ISSN:0023-2173
1432-1440
DOI:10.1007/BF01477029