Comparison of phenytoin determinations in plasma, plasma dialysate and saliva for control of antiepileptic therapy in children

Phenytoin was determined in plasma or serum, dialysate from plasma or serum and saliva in 45 children and 7 adults by gas chromatography. 200 microliter of plasma were necessary for dialysis. Close correlations were found between phenytoin concentrations in the different media (r greater than or equ...

Full description

Saved in:
Bibliographic Details
Published in:Klinische Wochenschrift 1979-01, Vol.57 (2), p.93-94
Main Authors: Brügmann, G, Kleinau, E, Nolte, R, Petruch, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anticonvulsants - therapeutic use
Child
Child, Preschool
Humans
Phenytoin - analysis
Phenytoin - blood
Saliva - analysis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phenytoin was determined in plasma or serum, dialysate from plasma or serum and saliva in 45 children and 7 adults by gas chromatography. 200 microliter of plasma were necessary for dialysis. Close correlations were found between phenytoin concentrations in the different media (r greater than or equal to 0.95). Since in some cases the levels in saliva were extremely high in comparison to plasma and dialysate, precautions are advisable when using phenytoin determinations in saliva for therapeutic decisions. Clinical data from 15 children with high phenytoin levels suggest that there is no advantage in determining the unbound fraction of the drug in plasma for the control of antiepileptic therapy.
ISSN:0023-2173
1432-1440
DOI:10.1007/BF01491341