Effect of combined administration of furosemide and aspirin on urinary urate excretion in man

Furosemide (20 mg) was administered intravenously to 7 healthy volunteers, before and after 4 days of oral administration of aspirin in uricosuric dosage (1 g daily). Aspirin prevented the decrease in urinary urate excretion induced by furosemide, without interfering with its natriuretic action. Thi...

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Bibliographic Details
Published in:Klinische Wochenschrift 1979-12, Vol.57 (23), p.1299-1301
Main Authors: Mountokalakis, T, Rallis, D, Mayopoulou-Symvoulidou, D, Komninos, Z
Format: Article
Language:English
Subjects:
Adult
Aspirin - pharmacology
Drug Antagonism
Female
Furosemide - pharmacology
Humans
Kidney Tubules - drug effects
Male
Middle Aged
Sodium - urine
Uric Acid - urine
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Summary:Furosemide (20 mg) was administered intravenously to 7 healthy volunteers, before and after 4 days of oral administration of aspirin in uricosuric dosage (1 g daily). Aspirin prevented the decrease in urinary urate excretion induced by furosemide, without interfering with its natriuretic action. This finding is suggested to be the result of the opposite and independent effects of the two drugs on tubular reabsorption of urate.
ISSN:0023-2173
1432-1440
DOI:10.1007/BF01492986