Bone changes in alcoholic liver cirrhosis: a histomorphometrical analysis of 52 cases

Bone biopsies of 52 histologically confirmed alcoholic cirrhotic patients and 15 age- and sex-matched controls have been histomorphometrically analyzed determining trabecular bone volume (TBV), mineralized bone volume (MBV), and osteoid volume (OV). We also determined serum PTH, 25-OH-D3, calcitonin...

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Published in:Digestive diseases and sciences 1988-09, Vol.33 (9), p.1089-1095
Main Authors: JORGE-HERNANDEZ, J. A, GONZALEZ-REIMERS, C. E, TORRES-RAMIREZ, A, SANTOLARIA-FERNANDEZ, F, GONZALEZ-GARCIA, C, BATISTA-LOPEZ, J. N, PESTANA-PESTANA, M, HERNANDEZ-NIETO, L
Format: Article
Language:English
Subjects:
Adult
Aged
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Biopsy
Bone and Bones - metabolism
Bone and Bones - pathology
Calcium - blood
Calcium - urine
Female
Hormones - blood
Humans
Liver - pathology
Liver Cirrhosis, Alcoholic - metabolism
Liver Cirrhosis, Alcoholic - pathology
Magnesium - blood
Magnesium - urine
Male
Medical sciences
Middle Aged
Phosphorus - blood
Phosphorus - urine
Toxicology
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Summary:Bone biopsies of 52 histologically confirmed alcoholic cirrhotic patients and 15 age- and sex-matched controls have been histomorphometrically analyzed determining trabecular bone volume (TBV), mineralized bone volume (MBV), and osteoid volume (OV). We also determined serum PTH, 25-OH-D3, calcitonin, FSH, LH, estradiol, testosterone, T3 and T4, urine cortisol, routine liver function tests, serum and urinary calcium, phosphorus, and magnesium. We found a high prevalence of osteoporosis: TBV was significantly lower in cirrhotic patients (T = 7.23, P less than 0.001), 41 of them being in the range of osteoporosis; none of them had osteomalacia. Levels of all the above-mentioned hormones and electrolytes were almost normal, and no correlation was found between them and liver function tests, as occurred with the bone parameters.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01535783