Methane excretion and experimental colonic carcinogenesis

To examine the association between methane (CH4) excretion and experimental colonic carcinogenesis, we measured CH4 excretion in rats treated with the colonic carcinogen azoxymethane (AOM, 7 mg/kg weekly for 10 weeks) and paired controls. CH4 excretion was not initially detected in either experiment...

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Bibliographic Details
Published in:Digestive diseases and sciences 1990-02, Vol.35 (2), p.221-224
Main Authors: FLICK, J. A, HAMILTON, S. R, ROSALES, F. J, PERMAN, J. A
Format: Article
Language:English
Subjects:
Adenocarcinoma - chemically induced
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Animals
Azoxymethane
Biological and medical sciences
Colonic Neoplasms - chemically induced
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Male
Medical sciences
Methane - metabolism
Rats
Rats, Inbred F344
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Time Factors
Tumors
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Summary:To examine the association between methane (CH4) excretion and experimental colonic carcinogenesis, we measured CH4 excretion in rats treated with the colonic carcinogen azoxymethane (AOM, 7 mg/kg weekly for 10 weeks) and paired controls. CH4 excretion was not initially detected in either experimental or control groups, but all animals acquired positive CH4 excretion status by time of sacrifice (week 26). There was no difference between groups or among AOM-treated animals with and without tumors in the median time to onset of detectable CH4 excretion or in the amount of CH4 excreted. Our results fail to provide support for a link between CH4 excretion and experimental colonic dysplasia or adenocarcinoma.
ISSN:0163-2116
1573-2568
DOI:10.1007/BF01536766