Production of brefeldin-A

Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eupenicillium brefeldianum, (B.Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Industrial Microbiology 1995-07, Vol.15 (1), p.5-9
Main Authors: MCCLOUD, T. G, BURNS, M. P, MAJADLY, F. D, MUSCHIK, G. M, MILLER, D. A, POOLE, K. K, ROACH, J. M, ROSS, J. T, LEBHERZ, W. B
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - metabolism
Antineoplastic drugs. Cytokines
Biological and medical sciences
Biotechnology
Brefeldin A
Chromatography, High Pressure Liquid
Cyclopentanes - isolation & purification
Cyclopentanes - metabolism
Fermentation
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Industrial Microbiology
Penicillium - metabolism
Production of active biomolecules
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eupenicillium brefeldianum, (B.Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale.
ISSN:0169-4146
1476-5535
DOI:10.1007/BF01570006