Granular cell tumour of the breast

Eight cases of benign granular cell tumour of the breast are reported. Seven patients were women and one was male. The age at the time of the excision ranged from 17 to 73 (average 40.1) years. All tumours were positive for S-100 protein and negative for keratin, myoglobin and gross cystic disease f...

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1992-05, Vol.420 (3), p.219-226
Main Authors: DAMIANI, S, KOERNER, F. C, DICKERSIN, G. R, COOK, M. G, EUSEBI, V
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breast Neoplasms - pathology
Breast Neoplasms - ultrastructure
Cytoplasmic Granules - ultrastructure
Female
Granular Cell Tumor - pathology
Granular Cell Tumor - ultrastructure
Gynecology. Andrology. Obstetrics
Humans
Keratins - analysis
Male
Mammary gland diseases
Medical sciences
Microscopy, Electron
Myoglobin - analysis
S100 Proteins - analysis
Tumors
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Summary:Eight cases of benign granular cell tumour of the breast are reported. Seven patients were women and one was male. The age at the time of the excision ranged from 17 to 73 (average 40.1) years. All tumours were positive for S-100 protein and negative for keratin, myoglobin and gross cystic disease fluid protein. In two cases ultrastructural studies revealed findings identical to those in the previously reported cases of granular cell tumours. None of these cases were diagnosed preoperatively. In six cases the clinical and mammographic findings, and in one case the frozen section, led to an erroneous diagnosis of malignancy. The clinico-pathological features of the cases are delineated in order to draw attention to a benign condition which closely simulates malignancy.
ISSN:0174-7398
1432-2307
DOI:10.1007/BF01600274