Smooth muscle contraction bands in intestinal infarction

We studied microscopic sections of 24 cases of intestinal infarction looking for contraction bands (CB) in the muscularis propria of the bowel wall. Controls were 11 surgical and 11 autopsy cases from patients who did not suffer any form of ischaemic disease. The difference of CB frequency was signi...

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Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1992, Vol.420 (1), p.25-29
Main Authors: GUARINO, M, REALE, D, MICOLI, G, TRICOMI, P, ZUCCOLI, E, CRISTOFORI, E
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Infarction - pathology
Intermediate Filament Proteins - analysis
Intestines - blood supply
Ischemia - pathology
Male
Medical sciences
Muscle Contraction
Muscle, Smooth - pathology
Other diseases. Semiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Superoxides - metabolism
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Summary:We studied microscopic sections of 24 cases of intestinal infarction looking for contraction bands (CB) in the muscularis propria of the bowel wall. Controls were 11 surgical and 11 autopsy cases from patients who did not suffer any form of ischaemic disease. The difference of CB frequency was significant (P less than 0.001) in infarction versus the surgical control group. Moreover, within the study group the CB frequency was also related to the severity of the ischaemic lesion (P less than 0.01). With immunostaining, CB were not reactive with antibodies against vimentin, desmin, actin or myosin. We propose that CB genesis in intestinal smooth muscle is related to hypoxia, possibly through altered homeostasis of calcium and catecholamine metabolism.
ISSN:0174-7398
1432-2307
DOI:10.1007/BF01605980