Carcinogenicity studies of masheri: pyrolysed tobacco product, in vitamin-A-deficient Sprague Dawley rats

The carcinogenicity of long-term feeding of masheri extract to animals in a vitamin-A-sufficient (SLO+) and deficient (SLO-) state was studied in Sprague Dawley rats by feeding daily dose of 3 mg extract over a period of 21 months. The phase I activating enzymes, the glutathione (GSH)/glutathione S-...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1991, Vol.117 (1), p.50-54
Main Authors: Ammigan, N, Nair, U J, Lalitha, V S, Bhide, S V
Format: Article
Language:English
Subjects:
Adenoma - chemically induced
Animals
Benzopyrene Hydroxylase - metabolism
Carcinogenicity Tests
Carcinogens - toxicity
Cytochrome P-450 Enzyme System - metabolism
Glutathione - metabolism
Hot Temperature
Liver - drug effects
Liver - enzymology
Lung - drug effects
Lung - enzymology
Lung Neoplasms - chemically induced
Male
Nicotiana
Oxidoreductases, N-Demethylating - metabolism
Papilloma - chemically induced
Plant Extracts - toxicity
Plants, Toxic
Rats
Rats, Inbred Strains
Stomach Neoplasms - chemically induced
Time Factors
Tobacco, Smokeless - toxicity
Vitamin A - blood
Vitamin A - metabolism
Vitamin A Deficiency - metabolism
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Summary:The carcinogenicity of long-term feeding of masheri extract to animals in a vitamin-A-sufficient (SLO+) and deficient (SLO-) state was studied in Sprague Dawley rats by feeding daily dose of 3 mg extract over a period of 21 months. The phase I activating enzymes, the glutathione (GSH)/glutathione S-transferase (GST) detoxification system, and the hepatic and circulating levels of vitamins A and C were also monitored at 12 and 21 months. It was observed that the phase I enzyme activities were significantly higher in SLO+ than in SLO- rats at both 12 months and 21 months. Moreover, the SLO- masheri-treated animals also showed a decreased in the GSH/GST detoxification system while the reverse was observed in SLO+ group. Masheri extract treatment significantly lowered the hepatic and circulating levels of vitamin A while a concurrent increase was observed in the vitamin C level. The extract was found to be tumorigenic in both the SLO+ and SLO- groups. Benign tumours were observed in the SLO+ group while a high incidence of malignant tumours of the lung were observed in the SLO- group upon treatment with masheri extract.
ISSN:0171-5216
1432-1335
DOI:10.1007/BF01613196