Tolerance in patients with terminal renal insufficiency of high doses of cefotaxime

Eleven patients with terminal renal insufficiency requiring dialysis were treated with 3 X 2 g cefotaxime in an open study lasting five days when the clinical findings strongly indicated a serious bacterial infection. The effect of the administration of the high-dose antibiotic on the coagulation sy...

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Bibliographic Details
Published in:Infection 1985, Vol.13 Suppl 1 (S1), p.S151-S155
Main Authors: Höffler, D, Wittgens, T, Piper, C
Format: Article
Language:English
Subjects:
Adult
Blood Coagulation - drug effects
Cefotaxime - adverse effects
Cefotaxime - blood
Drug Tolerance
Electroencephalography
Female
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - metabolism
Male
Middle Aged
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Summary:Eleven patients with terminal renal insufficiency requiring dialysis were treated with 3 X 2 g cefotaxime in an open study lasting five days when the clinical findings strongly indicated a serious bacterial infection. The effect of the administration of the high-dose antibiotic on the coagulation system (Quick test, partial thromboplastin time, thrombin time, antithrombin III and platelets) and on brain function (EEG) was investigated. The serum levels showed that the serum concentrations were not abnormally high in cases of terminal renal insufficiency requiring dialysis. In contrast to previous investigations in other beta-lactam antibiotics, no changes in the coagulation system or EEG occurred. On the basis of these findings, no reduction in the dose appears necessary for cefotaxime, if therapy does not exceed five days.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01644238