Acute agranulocytosis after prolonged high-dose usage of intravenous dipyrone - a different mechanism of dipyrone toxicity ?

Two seriously injured trauma patients presenting with intense and progressive neutropenia are described. Bone marrow examination in both cases showed virtually absent granulopoiesis but normal erythropoiesis and megakaryopoiesis, allowing the diagnosis of acute agranulocytosis. Discontinuation of on...

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Bibliographic Details
Published in:Annals of hematology 1993-03, Vol.66 (3), p.153-155
Main Authors: SABBAGA, J, OSAWA, C, PAHL, F. H, VELLUTINI, E, PEREIRA, D, CECCONELLO, I
Format: Article
Language:English
Subjects:
Adolescent
Adult
Agranulocytosis - chemically induced
Biological and medical sciences
Brain Injuries - therapy
Dipyrone - administration & dosage
Dipyrone - adverse effects
Drug toxicity and drugs side effects treatment
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Toxicity: blood
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Description
Summary:Two seriously injured trauma patients presenting with intense and progressive neutropenia are described. Bone marrow examination in both cases showed virtually absent granulopoiesis but normal erythropoiesis and megakaryopoiesis, allowing the diagnosis of acute agranulocytosis. Discontinuation of only one drug (dipyrone) with no further treatment was required for normalization of blood parameters. The association of dipyrone with neutropenia is still debatable. The recent medical literature on dipyrone generation of agranulocytosis is reviewed.
ISSN:0939-5555
1432-0584
DOI:10.1007/BF01697627