Correlations between cytogenetics and morphology in myelodysplastic syndromes

In order to detect possible relationships between cytogenetic abnormalities and morphologic features in myelodysplastic syndromes (MDS), 48 patients with MDS were investigated. Clonal cytogenetic abnormalities were present in bone marrow cells from 27 patients (56%). The most frequent single anomaly...

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Bibliographic Details
Published in:Blut 1990-04, Vol.60 (4), p.223-227
Main Authors: VILA, L, CHARRIN, C, ARCHIMBAUD, E, TREILLE-RITOUET, D, FRAISSE, J, FELMAN, J, FIERE, D, GERMAIN, D
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Bone Marrow - pathology
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 11
Erythrocytes - pathology
Granulocytes - pathology
Hematologic and hematopoietic diseases
Humans
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Megakaryocytes - pathology
Myelodysplastic Syndromes - blood
Myelodysplastic Syndromes - genetics
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Summary:In order to detect possible relationships between cytogenetic abnormalities and morphologic features in myelodysplastic syndromes (MDS), 48 patients with MDS were investigated. Clonal cytogenetic abnormalities were present in bone marrow cells from 27 patients (56%). The most frequent single anomaly was del (5 q) (10 cases), followed by monosomy 7 (3 cases), trisomy 8 (3 cases) and del (20 q) (2 cases). Complex anomalies were present in 6 patients. Morphologically, according to the French-American-British (FAB) classification: 17 cases were considered as refractory anemia (RA), 17 as RA with excess of blasts (RAEB), 2 as RAEB in transformation, 2 as acquired idiopathic sideroblastic anemia and 10 as chronic myelomonocytic leukemia. With regard to the FAB classification, del (5 q) was often associated with RA and complex cytogenetic anomalies with RAEB. When myelodysplasia was studied in individual myeloid lineages, del (5 q) was associated with hypolobulated megakaryocytes, monosomy 7 with micromegakaryocytes and complex chromosomal anomalies with the association of two or more features of dysmegakaryocytopoiesis. Del (11 q) was associated with increased iron storage and del (20 q) with marked dyserythropoiesis. No correlation was observed between cytogenetic anomalies and features of dysgranulocytopoiesis.
ISSN:0006-5242
1432-0584
DOI:10.1007/BF01728788