Pharmacokinetics of isosorbide dinitrate, isosorbide-2-nitrate and isosorbide-5-nitrate in renal insufficiency after repeated oral dosage

The pharmacokinetics of isosorbide dinitrate (ISDN) and its two active metabolites isosorbide-2-nitrate (IS-2-N) and isosorbide-5-nitrate (IS-5-N) were studied in 20 patients with normal and impaired renal function after repeated oral doses of standard 20 mg tablets ISDN t.i.d. Blood samples were ta...

Full description

Saved in:
Bibliographic Details
Published in:Klinische Wochenschrift 1989-03, Vol.67 (6), p.342-348
Main Authors: Evers, J, Bonn, R, Boertz, A, Cawello, W, Dickmans, H A, Weiss, M
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Aged
Aged, 80 and over
Coronary Disease - blood
Coronary Disease - drug therapy
Female
Humans
Isosorbide Dinitrate - administration & dosage
Isosorbide Dinitrate - analogs & derivatives
Isosorbide Dinitrate - pharmacokinetics
Kidney Failure, Chronic - blood
Kidney Function Tests
Male
Metabolic Clearance Rate
Middle Aged
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pharmacokinetics of isosorbide dinitrate (ISDN) and its two active metabolites isosorbide-2-nitrate (IS-2-N) and isosorbide-5-nitrate (IS-5-N) were studied in 20 patients with normal and impaired renal function after repeated oral doses of standard 20 mg tablets ISDN t.i.d. Blood samples were taken in the steady-state on days 2 and 14, and the plasma concentrations were measured by electron capture capillary gas chromatography. We found a wide variation of pharmacokinetic parameters (AUCss0-8 and t1/2) of ISDN, IS-2-N, and IS-5-N in our patients. No correlation was detected between AUCss0-8 or t1/2 and the degree of renal insufficiency. No drug accumulation was observed after 14 days of administration.
ISSN:0023-2173
1432-1440
DOI:10.1007/BF01741389