Endotoxin-induced increase in leukocyte adherence and macromolecular permeability of postcapillary venules

Recent studies on neutrophil adherence to human endothelial cells in vitro have shown that endotoxin predominantly affects the endothelial cell rather than the neutrophil. Local, continuous topical application of endotoxin to the hamster cheek pouch microcirculation resulted in a reversible increase...

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Bibliographic Details
Published in:Agents and Actions 1990-01, Vol.29 (1-2), p.21-23
Main Authors: Svensjö, E, Erlansson, M, van den Bos, G C
Format: Article
Language:English
Subjects:
Animals
Arterioles - drug effects
Budesonide
Capillary Permeability - drug effects
Cell Adhesion - drug effects
Cricetinae
Dextrans - pharmacology
Endotoxins - pharmacology
Fluorescein-5-isothiocyanate - analogs & derivatives
Fluoresceins - pharmacology
In Vitro Techniques
Leukocytes - drug effects
Male
Mesocricetus
Neutrophils - drug effects
Pregnenediones - pharmacology
Veins - drug effects
Venules - drug effects
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Summary:Recent studies on neutrophil adherence to human endothelial cells in vitro have shown that endotoxin predominantly affects the endothelial cell rather than the neutrophil. Local, continuous topical application of endotoxin to the hamster cheek pouch microcirculation resulted in a reversible increase in number of leaky postcapillary venules. We have found that local application of a glucocorticoid (budesonide) for only 5 min in the hamster cheek pouch resulted in pronounced inhibition of mediator. We therefore studied the local effects of endotoxin on neutrophil adherence and macromolecular permeability in untreated control and budesonide treated hamsters.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01964708