The pharmacological modulation of delayed type hypersensitivity (DTH) reactions to topical oxazolone in mouse skin

DTH reactions in the skin represent an increasing cause of inflammatory dermatoses typically exemplified by allergic contact dermatitis (eczema). The "oxazolone mouse ear swelling assay" has been developed as a simple acute model for contact allergy in the skin. In a search for new topical...

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Bibliographic Details
Published in:Agents and Actions 1990-01, Vol.29 (1-2), p.65-67
Main Authors: Cavey, D, Bouclier, M, Burg, G, Delamadeleine, F, Hensby, C N
Format: Article
Language:English
Subjects:
Animals
Drug Hypersensitivity - physiopathology
Drug Hypersensitivity - prevention & control
Edema - chemically induced
Edema - prevention & control
Female
Hypersensitivity, Delayed - physiopathology
Hypersensitivity, Delayed - prevention & control
Kinetics
Mice
Mice, Inbred BALB C
Oxazoles - toxicity
Oxazolone - toxicity
Peroxidase - metabolism
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Summary:DTH reactions in the skin represent an increasing cause of inflammatory dermatoses typically exemplified by allergic contact dermatitis (eczema). The "oxazolone mouse ear swelling assay" has been developed as a simple acute model for contact allergy in the skin. In a search for new topical anti-inflammatory drugs acting against eczema, our first objective was to characterize the animal model used for our screening purposes in terms of: kinetics of the vascular and cellular components of the inflammatory reaction; pharmacological modulation by known anti-inflammatory agents. We were also interested to see whether the injection of oxazolone into sub-cutaneous air-pouches in sensitized mice could provide an easy method for the study of cellular migration phenomena in this model.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01964723