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The pharmacological modulation of delayed type hypersensitivity (DTH) reactions to topical oxazolone in mouse skin

DTH reactions in the skin represent an increasing cause of inflammatory dermatoses typically exemplified by allergic contact dermatitis (eczema). The "oxazolone mouse ear swelling assay" has been developed as a simple acute model for contact allergy in the skin. In a search for new topical...

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Published in:	Agents and Actions 1990-01, Vol.29 (1-2), p.65-67
Main Authors:	Cavey, D, Bouclier, M, Burg, G, Delamadeleine, F, Hensby, C N
Format:	Article
Language:	English
Subjects:	Animals Drug Hypersensitivity - physiopathology Drug Hypersensitivity - prevention & control Edema - chemically induced Edema - prevention & control Female Hypersensitivity, Delayed - physiopathology Hypersensitivity, Delayed - prevention & control Kinetics Mice Mice, Inbred BALB C Oxazoles - toxicity Oxazolone - toxicity Peroxidase - metabolism
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description	DTH reactions in the skin represent an increasing cause of inflammatory dermatoses typically exemplified by allergic contact dermatitis (eczema). The "oxazolone mouse ear swelling assay" has been developed as a simple acute model for contact allergy in the skin. In a search for new topical anti-inflammatory drugs acting against eczema, our first objective was to characterize the animal model used for our screening purposes in terms of: kinetics of the vascular and cellular components of the inflammatory reaction; pharmacological modulation by known anti-inflammatory agents. We were also interested to see whether the injection of oxazolone into sub-cutaneous air-pouches in sensitized mice could provide an easy method for the study of cellular migration phenomena in this model.
doi_str_mv	10.1007/BF01964723
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source	Springer Online Journal Archives (Through 1996)
subjects	Animals Drug Hypersensitivity - physiopathology Drug Hypersensitivity - prevention & control Edema - chemically induced Edema - prevention & control Female Hypersensitivity, Delayed - physiopathology Hypersensitivity, Delayed - prevention & control Kinetics Mice Mice, Inbred BALB C Oxazoles - toxicity Oxazolone - toxicity Peroxidase - metabolism
title	The pharmacological modulation of delayed type hypersensitivity (DTH) reactions to topical oxazolone in mouse skin
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