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Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum

Administration of 500 microng of histamine into the lateral brain ventricle of the rat produced a 50% increase in striatal HVA. The DA level remained unchanged. The histamine-mediated elevation of HVA was abolished by pre-treatment with the antihistaminic drug - mepyramine. Moreover atropine signifi...

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Bibliographic Details
Published in:Agents and Actions 1977-03, Vol.7 (1), p.27-30
Main Authors: Nowak, J Z, Maśliński, C
Format: Article
Language:English
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Summary:Administration of 500 microng of histamine into the lateral brain ventricle of the rat produced a 50% increase in striatal HVA. The DA level remained unchanged. The histamine-mediated elevation of HVA was abolished by pre-treatment with the antihistaminic drug - mepyramine. Moreover atropine significantly reduced the histamine-induced increase of HVA. It is concluded that histamine primarily activates cholinergic neurons and that the changes in DA metabolism are a consequence of an increased cholinergic activity.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01964877