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Cholinergic link in the histamine-mediated increase in homovanillic acid in the rat striatum
Administration of 500 microng of histamine into the lateral brain ventricle of the rat produced a 50% increase in striatal HVA. The DA level remained unchanged. The histamine-mediated elevation of HVA was abolished by pre-treatment with the antihistaminic drug - mepyramine. Moreover atropine signifi...
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Published in: | Agents and Actions 1977-03, Vol.7 (1), p.27-30 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Administration of 500 microng of histamine into the lateral brain ventricle of the rat produced a 50% increase in striatal HVA. The DA level remained unchanged. The histamine-mediated elevation of HVA was abolished by pre-treatment with the antihistaminic drug - mepyramine. Moreover atropine significantly reduced the histamine-induced increase of HVA. It is concluded that histamine primarily activates cholinergic neurons and that the changes in DA metabolism are a consequence of an increased cholinergic activity. |
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ISSN: | 0065-4299 1420-908X |
DOI: | 10.1007/BF01964877 |