Failure of calcitonin to inhibit collagen-induced arthritis in rats

Previous reports have demonstrated suppressive effects of salmon calcitonin (SCT) on inflammation and immune reactions. A rat model of arthritis induced by immunization with type II collagen was studied in an attempt to demonstrate antirheumatic and immunosuppressive actions of SCT. No inhibition of...

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Bibliographic Details
Published in:Agents and Actions 1982-12, Vol.12 (5-6), p.671-673
Main Authors: Stuart, J M, Bandy, P R, Pinals, R S, Townes, A S
Format: Article
Language:English
Subjects:
Animals
Arthritis - drug therapy
Arthritis, Experimental - immunology
Calcitonin - therapeutic use
Collagen - immunology
Female
Immunization
Rats
Rats, Inbred Strains
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Summary:Previous reports have demonstrated suppressive effects of salmon calcitonin (SCT) on inflammation and immune reactions. A rat model of arthritis induced by immunization with type II collagen was studied in an attempt to demonstrate antirheumatic and immunosuppressive actions of SCT. No inhibition of arthritis or of specific immune responses to collagen was found.
ISSN:0065-4299
1420-908X
DOI:10.1007/BF01965077