Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine

We studied the effects of lidocaine (L) and chlorromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibi...

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Bibliographic Details
Published in:Agents and Actions 1979-08, Vol.9 (3), p.239-243
Main Authors: Johnson, H G, Miller, M D
Format: Article
Language:English
Subjects:
Animals
Ascitic Fluid - cytology
Calcimycin - antagonists & inhibitors
Calcium - metabolism
Chlorpromazine - metabolism
Chlorpromazine - pharmacology
Histamine Release - drug effects
In Vitro Techniques
Lidocaine - metabolism
Lidocaine - pharmacology
Mast Cells - drug effects
Mast Cells - metabolism
p-Methoxy-N-methylphenethylamine - antagonists & inhibitors
Rats
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Summary:We studied the effects of lidocaine (L) and chlorromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentration caused enhancement in this function. Evidence was obtained that L 10(-4) M may displace Ca++ from the cell membranes.
ISSN:0065-4299
1420-908X
DOI:10.1007/bf01966694